B. Duygu 脰zpolat

Hibbitt Fellow

Duygu Ozpolat
Contact Information
Education
PhD, Cell and Molecular Biology, Tulane University, 2010
BS, Biology, Middle East Technical University, 2004
MBLAffiliation
Bell Center
Research Area
Cell Biology
Developmental Biology
Imaging
Regeneration
Lab Website

Reproductive cells are the cells that become eggs and sperm, and then have the potential to give rise to a whole organism. Many organisms (such as hydra, flatworms, earth worms, or sea stars) regenerate their reproductive organs and reproductive cells as a part of whole body regeneration. In contrast, humans and well-established research organisms lack this ability. The mechanisms of regenerating the reproductive cells are not understood but is one of the most impactful regeneration abilities. Understanding the mechanisms of regenerating this cell type would provide insight into the 鈥渕other of all stem cells鈥. The goal of our laboratory is to close this knowledge gap and define the cellular origins and molecular mechanisms of germ cell regeneration. What are the embryonic origins of cells involved in reproductive cell regeneration? Can any cell type regenerate reproductive cells, or are there limitations to which cells can replace them? How is the genome integrity maintained in regenerated reproductive cells?

To answer these questions, we combine many exciting techniques such as live-imaging, genome-editing, mRNA injections, and transgenesis. We use marine and aquatic segmented worms such as Dumeril's clam worm (), and the water nymph worm (Pristina leidyi).

News and Research Highlights
Selected Publications

(in press, JEZ-B) Kuehn E., Clausen D., Null R.W., Metzger B., Willis A., 脰zpolat B.D. Segment number threshold determines juvenile onset of germline cluster expansion in Platynereis dumerilii (2021) 

脰zpolat B.D., Randel N., Williams E.A., Bezares-Calder贸n L.A., Andreatta G., Balavoine G., Bertucci P., Ferrier D., Gambi M.C., Gazave E., Handberg-Thorsager M., Hardege J., Hird C., Hsieh Y., Hui J., Mutemi K.N., Schneider S.Q., Simakov O., Vergara H., Vervoort M., J茅kely G., Tessmar-Raible K., Raible F., Arendt D.  [EvoDevo%2012,%2010%20(2021).%20https%3A//doi.org/10.1186/s13227-021-00180-3]The nereid on the rise: Platynereis as a model system. EvoDevo 12, 10 (2021) (Emerging Systems Series)

Torres J.P., Lin Z., Watkins M., Salcedo P.F., Baskin R.P., Elhabian S., Safavi-Hemami H., Tun J., Saguil N., Fang Y., Urdaneta R.F., 脰zpolat B.D., Olivera B.M., Schmid E.W. Small molecule mimicry hunting strategy in the imperial cone snail, Conus imperialis. (2021)  12 Mar 2021: Vol. 7, no. 11

Kuehn E., Girard J., Stockinger A., Raible F., 脰zpolat B.D. A scalable culturing system for the marine annelid Platynereis dumerilii.  (2019)

脰zpolat B.D., Handberg-Thorsager M., Vervoort M., Balavoine G. Cell lineage and cell cycling analyses of the 4d micromere using live imaging in the marine annelid Platynereis dumerilii.  DOI: 10.7554/eLife.30463 (2017) 

脰zpolat B.D., Sloane E., Zattara E.E., Bely A.E. Plasticity and regeneration of gonads in the annelid Pristina leidyi.  . (2016)

脰zpolat B.D., Bely A.E. Developmental and molecular biology of annelid regeneration: a comparative review of recent studies. . (2016) (Review)

脰zpolat B.D., Bely A.E.. Gonad establishment during asexual reproduction in the annelid Pristina leidyi. 405(1):123鈥36. (2015)