Scott Chimileski headshot
Contact Information
Education
Postdoc, Harvard Medical School, 2015-2019
Ph.D., Genetics and Genomics, University of Connecticut, 2015
BA, Biological Sciences, University of Connecticut, 2008
MBLAffiliation
Location
Research Area
Research Area

Dr. Scott Chimileski is a microbiologist, imaging specialist and educator. He is a year-round resident scientist whose research interests center around structured microbial communities known as biofilms. Scott鈥檚 work on biofilms began when he trained at the Center for Biofilm Engineering at Montana State University as a doctoral student and spearheaded several studies that helped establish Haloferax volcanii as a model for biofilm biology in the domain Archaea. Scott continued advanced training in the imaging of microbial communities as a postdoctoral Research Fellow in the  at Harvard Medical School, including formal training in light, fluorescence, and electron microscopy at the Harvard Center for Nanoscale Systems. While in the Kolter Lab, he was a lab imaging specialist and supported an eclectic range of collaborative projects, from the maize root microbiome, to interactions between soil actinobacteria, swarming in Bacillus subtilis, and biofilm formation by pathogenic Erwinia bacteria within squash plants.

Scott is currently investigating biofilms formed by microbes within the human mouth, also known as the oral microbiome, where hundreds of bacterial species live and interact. He is focused on how interactions between bacteria, and with molecules secreted by human tissues, shape the spatial organization of microbial communities on the surfaces of human teeth (dental plaque) and the tongue. Working closely with co-investigators Jessica Mark Welch and Gary Borisy, Scott is developing a live-cell in vitro system for imaging spatial organization of human oral bacteria. His ultimate goal is to contribute to the understanding of how the ecology of oral biofilms interlinks with human physiology in the establishment and maintenance of a healthy oral microbiome.

Ultra-high resolution composite image of a bacterial colony biofilm. Photo credit: Scott Chimileski
Ultra-high resolution composite image of a bacterial colony biofilm. Photo credit: Scott Chimileski

In parallel with his research, Scott is active in the public engagement with microbial sciences. His work through these broader impacts includes an award-winning book co-authored with Roberto Kolter, , published by Harvard University Press. Roberto Kolter and Scott also guest curated the exhibition , open at the Harvard Museum of Natural History from 2018 through 2022. Public venues in Uruguay, Brazil, Colombia, China, Scotland, the UK, and Denmark adapted Scott鈥檚 imagery in several additional major science exhibitions. Scott has received three BioArt Awards from the Federation of American Societies for Experimental Biology (FASEB), and a Passion in Science Award for Arts and Creativity from New England Biolabs. His scientific imagery has been featured in many popular media outlets including , Wired, , The Atlantic, NPR, Smithsonian, , TED, and CBS Sunday Morning.

For more on Scott鈥檚 research imagery, see "," by Francis Collins on the NIH Director's Blog, and 鈥,鈥 written by John Rennie for Quanta Magazine.

Scott Chimileski works with
Sujit Datta
Assistant Professor of Chemical and Biological Engineering
Princeton University
Senior Investigator
Forsyth Institute
Andrew and Erna Viterbi Professor
MIT
Selected Publications

Chimileski S, Borisy G, Dewhirst F, Mark Welch J. . Proceedings of the National Academy of Sciences 2024; 121 (37) e2408654121.

Stager J, Harvey L, Chimileski S. Long-term cultural eutrophication in White and Walden Ponds (Concord, Massachusetts, USA), Thoreau's lakes of light. Lake and Reservoir Management. 2020; 37(1): 2-18.

Chimileski S, Kolter R. . Cambridge, Massachusetts and London, England: Harvard University Press; 2017. ISBN 9780674975910

Ouellette M, Jackson L, Chimileski S, Papke RT. Genome-wide DNA methylation analysis of Haloferax volcanii H26 and identification of DNA methyltransferase related PD-(D/E)XK nuclease family protein HVO_A0006. Frontiers in Microbiology 2015; 6:251.

Chimileski S, Franklin MJ, Papke RT. . BMC Biology 2014; 12:65.

Chimileski S, Dolas K, Naor A, Gophna U, Papke RT. Extracellular DNA metabolism in Haloferax volcanii. Frontiers in Microbiology 2014; 5:57.

Zerulla K, Chimileski S, N盲ther D, Gophna U, Papke RT, Soppa J. DNA as a phosphate storage polymer and the alternative advantages of polyploidy for growth or survival. PLoS One. 2014; 9(4).