New Research Organisms

A Renaissance of Biological Discovery

Scientists make use of many different organisms to address both fundamental questions in biology and development treatments for human disease. Examples of organisms used by biologists range from single celled organisms, such as bacteria, to more complex ones, such as mice. In recent years, scientists have come to rely heavily on a few “model” organisms that have well-developed tools and communities. MBL(��Ůֱ��) is committed to expanding the range of organisms that can be used in this way, and in creating the next generation of genetically tractable aquatic research organisms to understand the fundamental aspects of biology common to all life, including humans.

To facilitate this process, the MBLis identifying a range of promising species with remarkable properties, such as those with extreme regenerative abilities and others that rapidly adapt to environmental changes, and establishing robust protocols for raising these species in captivity. More importantly, we are adapting modern techniques, such as genome editing, to these species and thus nucleating cutting-edge biological discovery at the MBLand taking advantage of the largely untapped wealth of diversity found in our oceans. Investing in these resources will strategically position the MBLas a center for studying the many pressing biological questions that await exploration.

The New Research Organisms strategic initiative, along with the Imaging Innovation Initiative, supports all areas of research at the MBLincluding Regeneration and Development, Cell Biology. Microbiomes, and Ecosystems.

What Research Organisms Reveal MBLHuman Health

Much of what we know about human biology today comes from studies of marine organisms. Those discoveries have led to the development of new diagnostic tools and treatments for disease.

Sea urchins and surf clams, for example, have provided information about the complexities of cell division and fertility. Sea slugs have shed light on learning and memory, and squid have revealed how nerve cells communicate and transmit information. While our research with novel aquatic organisms will reveal much about basic biology, it will also have direct and indirect benefits to the study of human biology and the treatment of disease.

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The Next Frontier for Biological Discovery

Convening Scientists from Around the World

Marine organisms, with their many remarkable characteristics and traits, represent an exciting frontier for biological discovery. During the course of their evolution, the diversity of marine life has solved a myriad of complex problems, from thriving in extreme environments, to developing appendages and spinal cords that quickly regenerate, to building flexible bodies that can mimic the shape of objects around them.

Exploring life in the oceans will have profound effects on our understanding of biology and its applications to our own health and wellbeing.

Since its founding over a century ago, the MBLhas provided distinctive advantages for leading scientists from around the world, offering both laboratory space and an unencumbered research environment. Institutional boundaries are nonexistent at the MBLallowing MBLresident faculty, visiting faculty and students from the Advanced Training Courses, and other visiting scientists from all over the world to work together to tackle some of the most challenging questions in biology, biodiversity and ecology, and the nature of life in the oceans

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The MBLis poised to capitalize on a unique opportunity in the biological sciences to understand the living world around us. Most of our current understanding of the basic mechanisms of biology is based on just a handful of laboratory species that represent only a small sliver of the diversity of life on Earth. A vast array of life lies waiting to be understood – or even detected – in the oceans, the next frontier for discovery.

By supporting the ��Ůֱ��’s mission or attending public events, the general public can help the MBLfoster growth in utilizing new research organisms for advancing scientific discovery.

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